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KMID : 0869220180220020076
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Journal of Korean Geriatric Psychiatry
2018 Volume.22 No. 2 p.76 ~ p.83
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Comparisons of Neurocognitive Functions in Patients with Late-Life Depression versus Normal Elderly, and Association with Changes of Depressive Symptoms in a 3-Month Follow-Up
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Kim Hye-Won
Choi Kwan-Woo
Na Eun-Jin
Lee Han-Kyeong
Jeon Hong-Jin
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Abstract
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Objective：This study aimed to investigate the neurocognitive functions of patients with late-life depression compared to healthy controls and their association with improvement of depressive symptoms.
Methods：We compared the results of neurocognitive tests between 41 patients with late-life depression and 20 healthy controls at baseline and 3 months later prospectively. And then we investigated the association of change of cognitive function and improvement of depressive symptoms in patients with late-life depression.
Results：Patients with late-life depression showed significantly impaired results in neurocognitive tests especially in domains of language, memory and frontal executive function compared to healthy control. However, after 3 months of treatment of depression, there was no association between the change of results of neurocognitive tests and the changes of scores of Hamilton Depression Rating Scale (HAM-D).
Conclusion：Impairment of cognitive functions in late-life depression includes the domains of language, memory and executive function and after 3 months of treatment of depression, there was no association of improvement of depressive symptom and cognitive change in patients with late-life depression.
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KEYWORD
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Late-life depression, Neuropsychological assessment, Cognition
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